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BioXcell InVivoPlus anti-mouse CD8α克隆號YTS 169.4單克隆抗體能與小鼠CD8α反應。CD8抗原是一種跨膜糖蛋白，作為T細胞受體的共受體。與TCR一樣，CD8與抗原呈遞細胞(APC)展示的I類MHC分子結合。CD8主要在細胞毒性T細胞表面表達，但也可在胸腺細胞、自然殺傷細胞和一些樹突狀細胞亞群中發現。CD8最常見的存在形式是由一個CD8α和一個CD8β鏈組成的異二聚體，然而，它也可以是由兩個CD8α鏈組成的同二聚體。CD8α和CD8β鏈均與免疫球蛋白可變輕鏈具有顯著同源性。每個CD8鏈的分子量約為34 kDa。BioXcell InVivoPlus anti-mouse CD8α克隆號YTS 169.4抗體在體內使用時顯示出depleting活性。
產品詳情：
產品名稱 | InVivoPlus anti-mouse CD8α |
產品貨號 | BP0117 |
產品規格 | 5/25/50/100mg |
反應種屬 | Mouse |
克隆號 | YTS 169.4 |
同種型 | Rat IgG2b, κ |
免疫原 | CBA mouse thymocytes |
實驗應用 | in vivo CD8+ T cell depletion |
產品形式 | PBS, pH 7.0,Contains no stabilizers or preservatives |
純度 | >95%, Determined by SDS-PAGE |
聚合 | <5%, Determined by SEC |
無菌處理 | 0.2 µm filtration |
純化方式 | Protein G |
RRID | AB_10950145 |
分子量 | 150 kDa |
小鼠病原檢測 | Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
保存條件 | 抗體原液保存在4°C，不能冷凍保存。 |
推薦同型對照 | InVivoPlus rat IgG2b isotype control, anti-keyhole limpet hemocyanin（貨號BP0090） |
推薦抗體稀釋液 | InVivoPure pH 7.0 Dilution Buffer（貨號IP0070） |
為什么選擇InVivoPlus抗體？
InVivoPlus級別的產品內毒素含量更低，經過多種實驗驗證，更適合用于體內實驗研究
該產品自上市已被多篇SCI文獻引用，品質有保證，以下是部分已發表的文獻引用：
應用 | 文章 |
體內CD8+T細胞耗竭 (in vivo CD8+ T cell depletion) | 1. Vashist, N., et al. (2018). 'Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression' Front Immunol 9: 505. 2. Triplett, T. A., et al. (2018). 'Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme' Nat Biotechnol 36(8): 758-764. 3. Carmi, Y., et al. (2015). 'Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity' Nature 521(7550): 99-104. 4. Burrack, K. S., et al. (2015). 'Myeloid Cell Arg1 Inhibits Control of Arthritogenic Alphavirus Infection by Suppressing Antiviral T Cells' PLoS Pathog 11(10): e1005191. 5. Wensveen, F. M., et al. (2015). 'NK cells link obesity-induced adipose stress to inflammation and insulin resistance' Nat Immunol 16(4): 376-385. 6. Li, Z., et al. (2015). 'Pre-treatment of allogeneic bone marrow recipients with the CXCR4 antagonist AMD3100 transiently enhances hematopoietic chimerism without promoting donor-specific skin allograft tolerance' Transpl Immunol 33(2): 125-129. |
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